Description

Propanoic Acid, 3-Fluoro-2-Hydroxy-, (2S)- is a high-purity, single-enantiomer fluorinated hydroxy acid building block of significant interest in advanced organic synthesis. Its unique chiral structure, featuring both fluorine and a hydroxyl group on a short carbon chain, makes it a valuable precursor for creating complex molecules with tailored biological and physical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atom can improve lipophilicity, stability, and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Fluorine-Containing Material Science: Incorporated into specialty polymers and advanced materials to modify surface properties, stability, and performance characteristics.
• Biochemical Research: Utilized as a probe or building block in medicinal chemistry for studying enzyme mechanisms and structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific chiral and fluorinated motifs.

Basic Information

Product Name	Propanoic Acid, 3-Fluoro-2-Hydroxy-, (2S)-
CAS No.	97643-52-2
Molecular Formula	C3H5FO3
Molecular Weight	108.07 g/mol
Synonyms	(2S)-3-Fluoro-2-hydroxypropanoic acid; (S)-3-Fluoro-2-hydroxypropionic acid; L-3-Fluoro-2-hydroxypropanoic acid; (2S)-3-Fluoro-2-hydroxypropionic acid; 3-Fluoro-2-hydroxypropanoic acid (S)-enantiomer; Fluorohydroxypropanoic acid; 2-Hydroxy-3-fluoropropanoic acid (S)-form
EINECS	Contact for details

Quality Control

Every batch of Propanoic Acid, 3-Fluoro-2-Hydroxy-, (2S)- is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically by HPLC), chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its nature as a strong acid/organic solvent, it should be kept away from incompatible materials such as strong bases and oxidizing agents. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.