Description

Human IL-1Beta (Interleukin-1 Beta) is a potent pro-inflammatory cytokine that plays a critical role in immune and inflammatory responses. This high-purity recombinant protein is essential for research and development in immunology, drug discovery, and diagnostic applications. It is a key reagent for scientists and manufacturers in the pharmaceutical, biotechnology, and life science research sectors studying inflammatory diseases, vaccine adjuvants, and immune system modulation.

Application

• Biomedical Research: Used as a standard or stimulant in cell-based assays to study inflammatory pathways, cytokine signaling, and immune cell activation.
• Drug Discovery & Development: Serves as a critical target or tool compound for screening and validating potential anti-inflammatory therapeutics.
• Diagnostic Kit Manufacturing: Employed as a calibrated antigen in the production of ELISA kits and other immunoassays for the quantitative detection of IL-1β or related antibodies.
• Cell Culture & Stimulation: Used to induce and model inflammatory conditions in various primary cells and cell lines for functional studies.
• Vaccine Research: Investigated for its role as an immunomodulator and potential adjuvant in vaccine formulation studies.
• Quality Control & Standardization: Acts as a reference standard for the quality control of biologics and in-house assay calibration within production and QC laboratories.

Basic Information

Product Name	Human IL-1Beta
CAS No.	97599-21-8
Molecular Formula	C690H1110N186O210S10
Molecular Weight	Approx. 17.4 kDa
Synonyms	Interleukin-1 Beta; IL-1β; IL1B; Catabolin; Leukocytic Endogenous Mediator; Lymphocyte Activating Factor; Recombinant Human Interleukin-1 Beta; IL-1 Beta; IL-1, Beta; Preinterleukin 1 Beta; Pro-Interleukin-1-Beta
EINECS	Contact for details

Quality Control

Our Human IL-1Beta is produced under stringent conditions and undergoes rigorous quality testing to ensure high biological activity, purity, and consistency. Each batch is characterized using advanced analytical techniques, including SDS-PAGE, HPLC, and bioactivity assays. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use in a dry environment.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Determined by cell proliferation assay
Identification (Mass Spec)	Consistent with theoretical molecular weight
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.