Description

4-Epi-6-Epi Doxycycline is a key chemical intermediate and impurity standard derived from the tetracycline antibiotic class. This compound is of significant importance for pharmaceutical research, development, and quality control processes, particularly for ensuring the purity and efficacy of doxycycline-based medications. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions involved in antibiotic production, method validation, and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a certified impurity standard for the identification and quantification of related substances in doxycycline active pharmaceutical ingredients (APIs) and finished drug products.
• Analytical Research: Serves as a critical component in method development and validation for HPLC, LC-MS, and other chromatographic techniques in quality control laboratories.
• Process Chemistry: Acts as an intermediate or a marker in the synthesis and purification pathways of doxycycline and related tetracycline antibiotics.
• Regulatory Compliance: Essential for meeting pharmacopoeial requirements (e.g., USP, EP) which mandate the control of specified and unspecified impurities in pharmaceutical substances.
• Academic & Biomedical Research: Utilized in studies investigating the structure-activity relationships, degradation pathways, and metabolic profiles of tetracycline antibiotics.

Basic Information

Product Name	4-Epi-6-Epi Doxycycline
CAS No.	97583-08-9
Molecular Formula	C₂₂H₂₄N₂O₈
Molecular Weight	444.44 g/mol
Synonyms	4-Epi-6-Epi-Doxycycline; 6-Epi-4-Epi-Doxycycline; Doxycycline Impurity G; Doxycycline EP Impurity G; Doxycycline Related Compound G; (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide; α-6-Deoxy-5-oxytetracycline
EINECS	Contact for details

Quality Control

Our 4-Epi-6-Epi Doxycycline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for use as a reference material. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.