Description

(2R,5S)-2-Trichloromethyl-3-Oxa-1-Azabicyclo[3.3.0]Octan-4-One is a high-purity, stereochemically defined bicyclic lactam compound. It serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is essential for research and production in the pharmaceutical and fine chemical industries, where precise stereochemistry and high purity are non-negotiable for efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of carbapenem and other β-lactam antibiotics.
• Organic Synthesis Building Block: Used in asymmetric synthesis to construct complex molecules with defined stereocenters.
• Medicinal Chemistry Research: Valuable scaffold for drug discovery programs targeting bacterial infections.
• Process Chemistry Development: Employed in the scale-up and optimization of API manufacturing routes.
• Fine Chemical Production: Intermediate for the synthesis of specialty chemicals requiring a specific bicyclic lactam structure.

Basic Information

Product Name	(2R,5S)-2-Trichloromethyl-3-Oxa-1-Azabicyclo[3.3.0]Octan-4-One
CAS No.	97538-67-5
Molecular Formula	C7H8Cl3NO2
Molecular Weight	244.50 g/mol
Synonyms	(2R-cis)-2-(Trichloromethyl)-3-oxa-1-azabicyclo[3.3.0]octan-4-one; (5R)-2-(Trichloromethyl)hexahydro-3a,6a-epoxy-1H-pyrrolo[3,4-c]pyrrole-1,3,4,6(2H,3aH,5H,6aH)-tetrone (non-standard); 2-Trichloromethyl-3-oxa-1-azabicyclo[3.3.0]octan-4-one, (2R,5S)-; Carbapenem Intermediate; Bicyclic β-Lactam Synthon
EINECS	Contact for details

Quality Control

Our (2R,5S)-2-Trichloromethyl-3-Oxa-1-Azabicyclo[3.3.0]Octan-4-One is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.