Description

trans-Ceftibuten CAS NO 97519-40-9 is a third-generation, orally active cephalosporin antibiotic belonging to the carbacephem class. It is valued for its broad-spectrum activity against Gram-negative bacteria, including β-lactamase-producing strains, and its excellent bioavailability. This compound is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of advanced antibiotic formulations. Its stability profile makes it a key intermediate and active pharmaceutical ingredient (API) for combating respiratory and urinary tract infections.

Application

• Pharmaceutical API: Serves as the active pharmaceutical ingredient in oral antibiotic medications, particularly for respiratory infections like bronchitis and pneumonia.
• Veterinary Pharmaceuticals: Used in the formulation of antibacterial treatments for companion animals and livestock.
• Research & Development: A critical reference standard and building block in microbiological research and the development of new antimicrobial agents.
• Generic Drug Manufacturing: Essential for the production of generic versions of ceftibuten-based drugs, ensuring cost-effective treatment options.
• Clinical Trial Materials: Supplied as a high-purity compound for use in preclinical and clinical studies evaluating new antibiotic therapies.
• Intermediate Synthesis: Acts as a key chiral intermediate in the synthetic pathways of other advanced cephalosporin derivatives.

Basic Information

Product Name	trans-Ceftibuten
CAS No.	97519-40-9
Molecular Formula	C15H14N4O6S2
Molecular Weight	410.42 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-2-butenoylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Ceftibuten (trans-isomer); Cedax (trans-isomer); 7432-S; Sch 39720; trans-7-[2-(2-Aminothiazol-4-yl)-4-carboxybut-2-enamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-Ceftibuten is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm isomeric identity, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) that detail compliance with in-house specifications aligned with ICH guidelines. Our quality commitment ensures the material is suitable for GMP-grade pharmaceutical applications and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere (e.g., nitrogen) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Isomeric Purity (Chiral HPLC)	≥99.0% (trans-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.