Description

Cefotaxime S-Oxide is a key pharmaceutical intermediate and oxidative impurity of the third-generation cephalosporin antibiotic, Cefotaxime. Its precise synthesis and high purity are critical for ensuring the safety, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). This compound is essential for manufacturers and research institutions focused on antibiotic development, quality control, and impurity profiling within the pharmaceutical and fine chemical sectors.

Application

• Pharmaceutical Impurity Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Cefotaxime S-Oxide impurity in Cefotaxime sodium API, crucial for HPLC and LC-MS analysis.
• API Development and Synthesis: Serves as a critical intermediate or starting material in the research and process development for novel cephalosporin antibiotics.
• Quality Control & Assurance (QC/QA): Employed in pharmaceutical quality control laboratories to validate analytical methods, monitor manufacturing processes, and ensure batch-to-batch consistency.
• Regulatory Compliance & Documentation: Supports the preparation of regulatory submission dossiers (e.g., for FDA, EMA) by providing necessary impurity data for drug master files (DMFs).
• Metabolic and Stability Studies: Used in research to study the degradation pathways and stability profile of Cefotaxime under various conditions.
• Academic and Industrial Research: A valuable compound for chemical and pharmacological research exploring the structure-activity relationships (SAR) of β-lactam antibiotics.

Basic Information

Product Name	Cefotaxime S-Oxide
CAS No.	97466-27-8
Molecular Formula	C16H17N5O8S2
Molecular Weight	479.47 g/mol
Synonyms	(6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid S-oxide; Cefotaxime Sulfoxide; Cefotaxime Impurity F (EP); Cefotaxime Related Compound F (USP); (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, acetate (ester), 5-oxide; Antibiotic HR 756 S-Oxide
EINECS	Contact for details

Quality Control

Our Cefotaxime S-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for use as a reference standard and pharmaceutical intermediate. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.