Description

n-(tert-Butoxycarbonyl)Glycine-1-13C is a stable isotope-labeled derivative of the amino acid glycine, where the carbon at the 1-position is enriched with the 13C isotope. This compound is a critical building block in the synthesis of isotopically labeled peptides and proteins for advanced research applications, providing a non-radioactive tracer for metabolic and pharmacokinetic studies. It is essential for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and nuclear magnetic resonance (NMR) spectroscopy who require high-purity, chemically defined labeled intermediates.

Application

• Pharmaceutical Research & Development: As a key precursor in the solid-phase and solution-phase synthesis of 13C-labeled peptides for drug discovery and metabolic pathway analysis.
• Proteomics & Biomarker Studies: Used in quantitative mass spectrometry (MS) to create internal standards for the accurate measurement of protein expression and post-translational modifications.
• NMR Spectroscopy: Serves as a valuable tool for structural elucidation and dynamics studies of biomolecules, leveraging the 13C label for enhanced spectral clarity and sensitivity.
• Stable Isotope Labeling (SIL): Employed in the production of isotopically labeled compounds for use in clinical research and diagnostic agent development.
• Bioconjugation & Chemical Biology: Facilitates the site-specific introduction of a labeled, Boc-protected glycine moiety into larger molecular constructs for tracking and imaging purposes.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)Glycine-1-13C
CAS No.	97352-64-2
Molecular Formula	C7H13NO4 (with 13C at position 1)
Molecular Weight	175.18 g/mol (13C labeled)
Synonyms	Boc-Glycine-1-13C; (tert-Butoxycarbonyl)glycine-1-13C; N-Boc-glycine-1-13C; 2-[[(tert-Butoxycarbonyl)amino]acetic-1-13C acid; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-13C; Boc-13C1-Gly-OH; NSC 334904; 13C Labeled Boc-Glycine
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)Glycine-1-13C is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive research applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications, including assay, isotopic purity, and impurity profile, are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (13C)	≥99 atom %
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.