Description

Na, Ne-Bis-Boc-L-Lysine tert-Butyl Ester is a protected derivative of the essential amino acid L-lysine, featuring tert-butyl ester and Boc (tert-butoxycarbonyl) protecting groups on its side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical manufacturers for the production of therapeutic peptides, research biochemicals, and novel drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of L-lysine residues into peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Linker Chemistry: Used to introduce functionalized lysine side chains for attaching payloads, labels, or polyethylene glycol (PEG) chains in antibody-drug conjugates (ADCs) and other bioconjugates.
• Research Biochemicals: Employed in academic and industrial laboratories for studying protein-protein interactions, enzyme kinetics, and signal transduction pathways.
• Combinatorial Chemistry Libraries: A valuable scaffold for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Custom Peptide Service Providers: A standard reagent for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis services.

Basic Information

Product Name	Na, Ne-Bis-Boc-L-Lysine tert-Butyl Ester
CAS No.	97347-28-9
Molecular Formula	C₂₅H₄₆N₂O₈
Molecular Weight	502.65 g/mol
Synonyms	Nα,Nε-Bis-Boc-L-lysine tert-butyl ester; Nα,Nε-Bis(tert-butoxycarbonyl)-L-lysine tert-butyl ester; Boc-Lys(Boc)-OtBu; H-Lys(Boc)₂-OtBu; tert-Butyl Nα,Nε-bis[(tert-butoxy)carbonyl]-L-lysinate; (2S)-6-{[(2-Methylpropan-2-yl)oxy]carbonylamino}-2-{[(2-methylpropan-2-yl)oxy]carbonylamino}hexanoic acid tert-butyl ester; Lys(Boc,Boc)-OtBu; L-Lysine, N2,N6-bis[(1,1-dimethylethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for fine chemicals and pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to strict quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.