Description

1-Fluoro-4-Isobutoxybenzene is a high-purity fluorinated aromatic ether building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, where the introduction of fluorine and an alkoxy group can dramatically alter biological activity and physical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drug candidates where fluorine substitution is critical for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom to enhance product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), contributing to improved electronic and optical properties.
• Polymer & Resin Modifier: Employed to introduce fluorine and aromatic ether functionalities into polymers, enhancing characteristics like chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Acts as a reliable starting material or coupling partner in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution for constructing complex aromatic systems.
• Chemical Research & Development: Essential for academic and industrial research labs exploring new fluorination methodologies and the structure-activity relationships of aromatic compounds.

Basic Information

Product Name	1-Fluoro-4-Isobutoxybenzene
CAS No.	97295-04-0
Molecular Formula	C10H13FO
Molecular Weight	168.21 g/mol
Synonyms	4-Fluoro-1-isobutoxybenzene; p-Fluoroisobutoxybenzene; 1-Fluoro-4-(2-methylpropoxy)benzene; Isobutyl 4-fluorophenyl ether; 4-Fluorophenyl isobutyl ether; Benzene, 1-fluoro-4-(2-methylpropoxy)-; (4-Fluorophenoxy)-2-methylpropane
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-Isobutoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical properties are provided with each shipment and are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥98.0% (Area %)
Water Content (KF)	≤0.5%
Related Substances (GC/HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%
Refractive Index (n20D)	1.470 - 1.480
Density (g/mL at 20°C)	1.010 - 1.030

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.