Description

Sodium (2E)-n-((6R,7R)-3-((Carbamoyloxy)Methyl)-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Furan-2-Yl)-2-(Methoxyimino)Acetimidate is a key pharmaceutical intermediate, specifically the sodium salt of a cephalosporin derivative. This compound is critical for ensuring the stability and bioavailability of advanced β-lactam antibiotics during synthesis and formulation. It is primarily required by manufacturers in the pharmaceutical industry for the production of high-purity, broad-spectrum antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A crucial intermediate in the multi-step synthesis of third-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for developing new antibacterial compounds and studying structure-activity relationships.
• Sterile Injectable Formulations: Serves as a precursor for preparing stable, soluble salt forms of antibiotics intended for parenteral administration.
• Process Chemistry Optimization: Employed in scaling up and optimizing manufacturing processes for cost-effective and high-yield antibiotic production.
• Quality Control Reference Standards: Utilized as a certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	Sodium (2E)-n-((6R,7R)-3-((Carbamoyloxy)Methyl)-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Furan-2-Yl)-2-(Methoxyimino)Acetimidate
CAS No.	97232-49-0
Molecular Formula	C20H19N5O9SNa
Molecular Weight	528.45 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Furyl)-2-(methoxyimino)acetamido]-3-[(aminocarbonyl)oxy]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; Cefuroxime Sodium Impurity; Sodium Cefuroxime Intermediate; Cefuroxime Axetil Intermediate Sodium Salt; (Z)-Cefuroxime Sodium; 7-[2-(2-Furyl)-2-(Methoxyimino)acetamido]-3-[(aminocarbonyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; Antibiotic Intermediate 97232-49-0
EINECS	Contact for details

Quality Control

Our Sodium (2E)-n-((6R,7R)-3-((Carbamoyloxy)Methyl)-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Furan-2-Yl)-2-(Methoxyimino)Acetimidate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and conformity to pharmaceutical-grade standards. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a dry environment to prevent moisture absorption. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.