Description

Substance P (6-11), N(Alpha)-(3-Iododesaminotyrosyl)- is a specific, iodinated fragment analog of the neuropeptide Substance P. This modified peptide is a critical research tool for studying neurokinin-1 (NK-1) receptor binding, signal transduction, and the physiological roles of Substance P in pain, inflammation, and neurotransmission. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers in neuroscience, immunology, and drug discovery programs.

Application

• Neuroscience Research: As a labeled ligand for receptor binding assays and autoradiography to map NK-1 receptor distribution in the central and peripheral nervous systems.
• Drug Discovery & Development: A key reference standard and pharmacological tool for screening and characterizing novel NK-1 receptor antagonists and agonists.
• Biochemical Assays: Used in competitive inhibition studies to determine binding affinities (IC50/Ki values) and investigate receptor-ligand interaction mechanisms.
• Inflammation & Pain Pathway Studies: Employed in experimental models to elucidate the role of Substance P in neurogenic inflammation, nociception, and immune cell communication.
• Diagnostic Development: Potential use in the development of in vitro diagnostic (IVD) kits and imaging probes targeting Substance P pathways.

Basic Information

Product Name	Substance P (6-11), N(Alpha)-(3-Iododesaminotyrosyl)-
CAS No.	97207-37-9
Molecular Formula	C41H58N10O9I
Molecular Weight	985.88 g/mol
Synonyms	N(Alpha)-(3-Iododesaminotyrosyl)-Substance P (6-11); [Tyr6(3-I), D-Phe7, D-His9]-Substance P (6-11); [Tyr6(3-I), D-Phe7, Nle11]-Substance P (6-11) amide (common research notation); Iodinated Substance P fragment 6-11; NK-1 Receptor Ligand Fragment; SP (6-11) Iodo-Analog
EINECS	Contact for details

Quality Control

Our Substance P (6-11), N(Alpha)-(3-Iododesaminotyrosyl)- is manufactured under strict quality systems suitable for research use. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order to ensure traceability and reproducibility for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.