Description

Insulin-Like Growth Factor I, Thr(59)- is a bioactive, recombinant protein analog of human IGF-1 with a specific threonine substitution at position 59. This modification can influence its receptor binding affinity and metabolic stability, making it a valuable tool for advanced biochemical and pharmaceutical research. It is essential for researchers and developers in the fields of endocrinology, metabolic disease studies, and biopharmaceutical development who require high-purity, well-characterized growth factors.

Application

• Biomedical Research: Used as a critical reagent in studying cell proliferation, differentiation, and apoptosis mechanisms, particularly in muscle, bone, and nerve cells.
• Drug Discovery & Development: Serves as a reference standard or active pharmaceutical ingredient (API) in the development of novel therapeutics for growth disorders and metabolic diseases.
• Cell Culture & Tissue Engineering: Added to serum-free media formulations to promote the growth and maintenance of specific cell lines in vitro.
• Signal Pathway Analysis: Employed to investigate the intricacies of the IGF-1 signaling pathway and its cross-talk with other hormonal systems.
• Comparative Bioactivity Studies: Utilized to compare the potency and functional profile against native IGF-1 and other analogs.

Basic Information

Product Name	Insulin-Like Growth Factor I, Thr(59)-
CAS No.	97199-03-6
Molecular Formula	C~860~H~1343~N~233~O~253~S~7~
Molecular Weight	~7.6 kDa
Synonyms	IGF-1 Thr59; IGF-I (Thr59); Recombinant IGF-1 Analog; Insulin-like growth factor I (Thr59); Somatomedin C analog; Mechano Growth Factor related peptide; [Thr59]-IGF-I; IGF-1 variant
EINECS	Contact for details

Quality Control

Our Insulin-Like Growth Factor I, Thr(59)- is produced and tested under stringent quality systems. Each batch is characterized to ensure identity, purity, and biological activity, aligning with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing results for purity (HPLC), molecular weight confirmation (MS), endotoxin levels, and bioassay potency is provided to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Biological Activity	Determined by cell proliferation assay
Endotoxin	< 1.0 EU/µg
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.