Description

cis-β-Hydroxy Tamoxifen CAS NO 97151-04-7 is a key active metabolite and synthetic intermediate of the widely used selective estrogen receptor modulator (SERM), Tamoxifen. This compound is critical for pharmaceutical research and development, particularly in the study of breast cancer therapeutics and endocrine-related pathways. It serves as an essential reference standard and a vital building block for medicinal chemists, analytical laboratories, and advanced pharmaceutical manufacturers developing next-generation SERMs and targeted cancer treatments.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in the production of Tamoxifen and its related drug formulations.
• Active Pharmaceutical Ingredient (API) Intermediate: A crucial synthetic precursor in the manufacturing process of Tamoxifen citrate and its metabolites.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate estrogen receptor (ER) binding affinity, mechanism of action, and metabolic pathways of SERMs.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the bioactivation and efficacy profile of Tamoxifen therapy.
• Drug Discovery & Development: Serves as a core structural template for the design and synthesis of novel SERM candidates with improved selectivity and reduced side effects.
• Diagnostic Kit Development: Utilized in the calibration and development of immunoassays and other diagnostic tools for monitoring Tamoxifen levels in patients.

Basic Information

Product Name	cis-β-Hydroxy Tamoxifen
CAS No.	97151-04-7
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	(Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; (Z)-Hydroxytamoxifen; cis-4-Hydroxytamoxifen; (Z)-4-Hydroxytamoxifen; β-Hydroxytamoxifen (cis-isomer); Afimoxifene (cis-isomer); Metabolite B of Tamoxifen; Endoxifen (cis-isomer)
EINECS	Contact for details

Quality Control

Our cis-β-Hydroxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of related substances and residual solvents. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with cGMP guidelines for advanced pharmaceutical intermediates. Specifications are designed to meet the rigorous demands of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.