Description

3-T-Butyldimethylsiloxypropyllithium is a highly reactive organolithium reagent, specifically a silyl-protected lithium alkoxide, used for precise carbon-carbon bond formation in complex organic syntheses. Its core value lies in its ability to act as a nucleophilic synthon for introducing the 3-(tert-butyldimethylsiloxy)propyl group under controlled conditions, enabling the construction of advanced molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialized intermediates for developing active ingredients and functional polymers.

Application

• As a key nucleophilic building block in the total synthesis of complex natural products and pharmaceutical active pharmaceutical ingredients (APIs).
• For the introduction of functionalized alkyl chains in the development of novel agrochemicals and fine chemicals.
• In polymer chemistry as an initiator or functional chain-end modifier for synthesizing specialty polymers with tailored properties.
• As a reagent in advanced material science for the surface functionalization of nanoparticles and other substrates.
• Utilized in methodological organic chemistry research for developing new catalytic and stoichiometric C-C bond-forming reactions.

Basic Information

Product Name	3-T-Butyldimethylsiloxypropyllithium
CAS No.	97057-70-0
Molecular Formula	C9H21LiOSi
Molecular Weight	188.30 g/mol
Synonyms	Lithium 3-[(tert-Butyldimethylsilyl)oxy]propan-1-ide; 3-(tert-Butyldimethylsiloxy)propyllithium; 3-(TBDMSO)propyllithium; (3-Lithiopropoxy)(tert-butyl)dimethylsilane; TBDMSO(CH2)3Li; 1-Lithio-3-(tert-butyldimethylsiloxy)propane; 3-(tert-Butyldimethylsilyloxy)-1-propyllithium
EINECS	Contact for details

Quality Control

Our production of 3-T-Butyldimethylsiloxypropyllithium adheres to stringent quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized by NMR spectroscopy and titration to confirm identity and assay purity. Certificates of Analysis (COA) detailing specific analytical results are provided with every shipment. We operate under a quality management system to support our commitment to supplying reagents that meet the exacting standards of research and process development.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong base/organic solvent mixture that is easily oxidized and highly volatile, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. The container must be kept tightly sealed in a cool, dry, and well-ventilated area, away from moisture and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 0.5 M in specified solvent (e.g., cyclohexane/ether)
Purity (GC/HPLC)	Contact for details
Solvent System	As specified per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.