Description

2-Lithiofuran is a highly reactive organolithium reagent, a key building block for introducing the furan heterocycle into complex molecular architectures. Its value lies in enabling efficient carbon-carbon bond formation, which is critical for synthesizing advanced pharmaceutical intermediates, agrochemicals, and specialty materials. This compound is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors seeking to create novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing furan-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Production: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate the furan ring for enhanced biological activity.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalization agent for creating specialized polymers, conductive materials, and liquid crystals.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex fragrance molecules, dyes, and other high-value specialty chemicals.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed reactions (e.g., Negishi, Suzuki-Miyaura-type couplings) for biaryl formation.
• Academic & Industrial R&D: A fundamental tool for methodological development and exploring new chemical space in heterocyclic chemistry.

Basic Information

Product Name	2-Lithiofuran
CAS No.	141957-80-4
Molecular Formula	C4H3LiO
Molecular Weight	74.00 g/mol
Synonyms	2-Furyllithium; Furan-2-yllithium; Lithium furan-2-ide; 2-Lithiumfuran; 2-Furanyllithium; Lithiofuran; 2-Furyl lithium
EINECS	Contact for details

Quality Control

Every batch of 2-Lithiofuran is manufactured and tested under stringent quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as concentration (typically supplied in solution), assay by titration, and the absence of deleterious impurities. Our quality systems are designed to support cGMP and ISO standards for advanced intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile, easily oxidized (store under inert atmosphere), and strong alkali/organic solvent nature, this reagent must be stored under a dry, inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Handle only in a certified fume hood using appropriate techniques for pyrophoric and air-sensitive materials.

Specification

Item	Specification
Appearance (Solution)	Colorless to pale yellow
Concentration	Typically 1.0M to 2.0M in specified solvent (e.g., THF, Diethyl ether)
Assay (Titration)	≥ 95.0%
Identification (IR/NMR)	Conforms to structure
Solvent (Carrier)	As specified (e.g., Tetrahydrofuran)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.