Description

Lithium Diisopropylamide Mono(Tetrahydrofuran) is a highly reactive, non-nucleophilic strong base commonly supplied as a solution in tetrahydrofuran. This compound matters for its exceptional ability to deprotonate a wide range of weakly acidic substrates, enabling critical bond-forming reactions in complex molecule synthesis. It is an essential reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and reliable deprotonation agents.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the generation of enolates in the synthesis of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in the preparation of chiral auxiliaries and for stereoselective deprotonations.
• Polymer Chemistry: Employed as an initiator or catalyst in anionic polymerization processes for specialty polymers.
• Agrochemical Manufacturing: Facilitates the synthesis of complex heterocyclic compounds used in crop protection agents.
• Fine Chemical Production: Critical for regioselective and chemoselective deprotonation steps in multi-step synthetic sequences.
• Academic & Industrial R&D: A staple in research laboratories for method development and exploring new synthetic pathways.

Basic Information

Product Name	Lithium Diisopropylamide Mono(Tetrahydrofuran)
CAS No.	123333-84-6
Molecular Formula	C7H16LiN • C4H8O
Molecular Weight	179.19 g/mol (LDA) + 72.11 g/mol (THF adduct)
Synonyms	LDA-THF Complex; Lithium Diisopropylamide THF Adduct; Lithium Bis(1-methylethyl)amide compound with Tetrahydrofuran (1:1); Diisopropylaminolithium-THF; LDA (THF solvate); N-Lithiodiisopropylamine Tetrahydrofuran Adduct; 2-Propanamine, N-(1-methylethyl)-, lithium salt, compd. with oxolane (1:1)
EINECS	Contact for details

Quality Control

Our Lithium Diisopropylamide Mono(Tetrahydrofuran) is manufactured under stringent controls to ensure batch-to-batch consistency and high reactivity. Quality is verified through comprehensive analytical testing, including titration for assay and impurity profiling. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Due to its highly volatile and moisture-sensitive nature, the container should be kept sealed and handled under anhydrous conditions. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0% (as LDA)
Concentration (Typical)	1.0 M in THF
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.