Description

(S)-4-Benzyl-2-Oxazolidinone Lithium Salt is a high-value chiral auxiliary and organolithium reagent used in asymmetric synthesis. This compound matters for its critical role in facilitating stereoselective carbon-carbon bond formation, enabling the production of enantiomerically pure intermediates. Pharmaceutical, agrochemical, and advanced material research laboratories need it for developing novel active ingredients and fine chemicals with precise chiral configurations.

Application

• As a chiral auxiliary in the Evans aldol reaction for the asymmetric synthesis of β-hydroxy carbonyl compounds.
• For the stereocontrolled alkylation of enolates in the production of non-racemic α-amino acids and other chiral building blocks.
• In the synthesis of complex natural products and active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• As a reagent in the preparation of catalysts and ligands for asymmetric hydrogenation and other enantioselective transformations.
• For research and development in medicinal chemistry focused on novel therapeutic agents.
• In the scale-up and process development of chiral intermediates for agrochemicals and specialty chemicals.

Basic Information

Product Name	(S)-4-Benzyl-2-Oxazolidinone Lithium Salt
CAS No.	123731-35-1
Molecular Formula	C10H10LiNO2
Molecular Weight	183.13 g/mol
Synonyms	(4S)-4-Benzyl-1,3-oxazolidin-2-one lithium salt; (S)-(-)-4-Benzyl-2-oxazolidinone lithium salt; Evans Chiral Auxiliary Lithium Salt; Lithium (S)-4-benzyl-2-oxazolidinonate; (S)-4-Benzyl-2-oxazolidinone Li salt; (S)-BOX Li salt; (S)-N-Benzyloxazolidinone lithium enolate precursor
EINECS	Contact for details

Quality Control

Our (S)-4-Benzyl-2-Oxazolidinone Lithium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic chemistry applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.