Description

Lithium, [4-(1,1-Dimethylethyl)-2-Thiazolyl]- (9Ci) is a specialized organolithium reagent featuring a sterically hindered tert-butyl-substituted thiazole moiety. This compound matters as a powerful and selective base or nucleophile in advanced organic synthesis, enabling the formation of complex carbon-lithium bonds under controlled conditions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel heterocyclic frameworks and fine chemical intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Employed as a key lithiating agent for the regioselective functionalization of complex heterocycles and active pharmaceutical ingredient (API) precursors.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require the introduction of specific thiazole-based structural motifs.
• Advanced Material Development: Serves as a monomer or building block in the synthesis of specialty polymers, ligands for catalysts, and organic electronic materials.
• Academic & Industrial R&D: A valuable tool for methodological development in organometallic chemistry and for exploring new reaction pathways in synthetic organic chemistry.
• Fine Chemical Production: Facilitates the large-scale, high-purity synthesis of specialty chemicals where precise molecular architecture is critical.

Basic Information

Product Name	Lithium, [4-(1,1-Dimethylethyl)-2-Thiazolyl]- (9Ci)
CAS No.	107531-44-2
Molecular Formula	C7H10LiNS
Molecular Weight	147.16 g/mol
Synonyms	2-(tert-Butyl)thiazolyllithium; 4-tert-Butyl-2-thiazolyllithium; Lithium 4-tert-butyl-2-thiazolide; 2-Lithio-4-tert-butylthiazole; 4-(1,1-Dimethylethyl)-2-thiazolyllithium; 4-tert-Butylthiazol-2-yllithium
EINECS	Contact for details

Quality Control

Every batch of Lithium, [4-(1,1-Dimethylethyl)-2-Thiazolyl]- (9Ci) is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing assay, impurity profile, and solution concentration are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this material must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. The container should be kept in a cool, dry, well-ventilated place, away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Solution (color may vary)
Identification (IR)	Conforms
Assay (Titration)	≥ 95% (as C7H10LiNS)
Concentration (Typical)	0.5 M to 2.0 M in specified solvent
Solvent	Specified (e.g., THF, Diethyl ether, Hexanes)
Moisture (Karl Fischer)	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.