Description

Boc-L-Alanine Thioamide is a protected amino acid derivative where the amine group is shielded by a tert-butoxycarbonyl (Boc) group and the carboxylic acid is converted to a thioamide. This compound is a versatile and critical building block in organic synthesis, particularly in the development of peptide mimetics and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of novel therapeutic agents.

Application

• Peptidomimetic Synthesis: A key intermediate for constructing peptide analogs where the thioamide group modifies backbone properties and biological activity.
• Medicinal Chemistry Research: Used in the design and synthesis of protease inhibitors, receptor ligands, and other pharmacologically active compounds.
• Heterocyclic Chemistry: Serves as a precursor for the synthesis of various nitrogen and sulfur-containing heterocycles, such as thiazoles and thiadiazoles.
• Chemical Biology Probes: Employed in the development of activity-based probes and tools for studying enzyme mechanisms and protein interactions.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) and fine chemicals.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized intermediates for clients.

Basic Information

Product Name	Boc-L-Alanine Thioamide
CAS No.	96929-01-0
Molecular Formula	C8H16N2O2S
Molecular Weight	204.29 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]propanethioamide; N-(tert-Butoxycarbonyl)-L-alanine thioamide; Boc-L-Ala-thioamide; Boc-Ala-NH2(S); (S)-2-((tert-Butoxycarbonyl)amino)propanethioamide; tert-Butyl (1S)-1-(aminothioxomethyl)ethylcarbamate; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, thioamide
EINECS	Contact for details

Quality Control

Our Boc-L-Alanine Thioamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (IR, NMR). We provide comprehensive Certificates of Analysis (COA) detailing all specifications to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.