Description

Triazolam n-Oxide is a significant pharmaceutical intermediate and metabolite of the benzodiazepine derivative triazolam. This compound is of critical importance in research and development for the synthesis of active pharmaceutical ingredients (APIs) and for analytical reference standards. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of benzodiazepine-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and regulatory compliance in pharmaceutical analysis.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolic pathways and biological activity of triazolam.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of triazolam and related pharmaceutical products.
• Research & Development: Utilized in academic and industrial R&D for exploring new chemical entities and pharmacological mechanisms.
• Regulatory Submissions: Provides necessary documentation and characterization data for drug master files (DMFs) and regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	Triazolam n-Oxide
CAS No.	96849-15-9
Molecular Formula	C17H12Cl2N4O
Molecular Weight	359.21 g/mol
Synonyms	8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine 4-Oxide; Triazolam 4-Oxide; Triazolam N-Oxide; Triazolam Metabolite; 1-Methyl-8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine 4-Oxide
EINECS	Contact for details

Quality Control

Our Triazolam n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed specifications to ensure compliance with research and pharmaceutical industry standards. Our quality commitment supports your needs for reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.