Description

Suprofen Acyl Glucuronide is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) Suprofen. This compound is of significant importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and toxicology. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory safety assessments.

Application

• Reference Standard for Bioanalysis: Used as an analytical standard in LC-MS/MS and HPLC methods for the quantitative determination of Suprofen and its metabolites in biological matrices.
• Metabolite Profiling & Identification: Essential for in vitro and in vivo metabolism studies to understand the metabolic pathways and clearance mechanisms of Suprofen.
• Toxicology and Safety Assessment: Employed in investigative toxicology to assess the potential role of reactive acyl glucuronide metabolites in drug-induced liver injury (DILI).
• Pharmacokinetic (PK) Studies: Serves as a critical calibrator for measuring metabolite exposure in PK studies to support drug development.
• Regulatory Submissions: Provides characterized material for use in studies required for regulatory filings with agencies like the FDA and EMA.
• Stability Testing: Used in forced degradation studies to understand the stability profile of the parent drug and its glucuronide conjugate.

Basic Information

Product Name	Suprofen Acyl Glucuronide
CAS No.	96740-53-3
Molecular Formula	C20H22O11
Molecular Weight	438.38 g/mol
Synonyms	Suprofen 1-O-β-Acyl Glucuronide; Suprofen Glucuronide; α-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid β-1-O-Glucuronide; Suprofen Acyl-β-D-Glucuronide; Suprofen Metabolite (Acyl Glucuronide); 2-[4-(2-Thienoyl)phenyl]propionic acid 1-O-β-glucuronide; Suprofen-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Suprofen Acyl Glucuronide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (NMR, IR, MS), purity assessment by HPLC, and determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.