Description

Atrial Natriuretic Peptide (6-33) is a bioactive fragment of the endogenous cardiac hormone, specifically comprising amino acid residues 6 through 33 of the full-length peptide. This compound is of significant value for cardiovascular and renal research, serving as a key tool for studying natriuresis, diuresis, and vasodilation mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on hypertension, heart failure, and related metabolic disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of natriuretic peptide receptors (NPR-A, NPR-C) and their signaling pathways.
• Pharmacological Assays: Employed in in vitro and in vivo models to evaluate blood pressure regulation, renal function, and cardiac load.
• Diagnostic Development: Serves as a critical calibrant and control in the development of immunoassays (ELISA, RIA) for detecting ANP-related biomarkers.
• Drug Discovery: Acts as a lead compound or comparator in the design and screening of novel therapeutic agents targeting cardiovascular diseases.
• Biochemical Studies: Utilized for investigating peptide structure-activity relationships (SAR) and enzyme degradation kinetics.

Basic Information

Product Name	Atrial Natriuretic Peptide (6-33)
CAS No.	96573-89-6
Molecular Formula	C136H226N46O41S4
Molecular Weight	3141.7 g/mol
Synonyms	ANP (6-33); Atriopeptin (6-33); Cardionatrin (6-33); Auriculin B (6-33); ANF (6-33); Atrial Natriuretic Factor (6-33); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Peptide (6-33) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for peptide synthesis, and our quality system is designed to meet the exacting standards of the pharmaceutical and life science industries.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assayed by receptor binding or functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.