Description

n-Nitrosooxprenolol is a specialized nitroso derivative of the β-blocker oxprenolol, identified by CAS number 96497-86-8. This compound is of significant interest in pharmaceutical research and development, particularly for studies involving nitrosamine impurities, metabolic pathways, and chemical stability. It serves as a critical reference standard and intermediate for analytical chemists, toxicologists, and process development scientists. Key industries that require this material include pharmaceutical R&D, contract research organizations (CROs), and analytical testing laboratories focused on drug safety and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of nitrosamine impurities in active pharmaceutical ingredients (APIs) and finished drug products.
• Analytical Research: Serves as a critical analyte in method development and validation for advanced analytical techniques like LC-MS/MS and HPLC to ensure regulatory compliance (e.g., ICH M7, FDA, EMA guidelines).
• Toxicological Studies: Employed in investigative toxicology and metabolism studies to understand the formation, fate, and potential risk of nitrosamine derivatives in biological systems.
• Process Chemistry & Impurity Control: Acts as a key intermediate or marker in developing and optimizing synthetic routes to mitigate or control the formation of genotoxic impurities during manufacturing.
• Quality Control & Assurance: Essential for in-house laboratory quality control protocols to calibrate equipment and verify analytical procedures for nitrosamine detection.
• Regulatory Submissions: Provides necessary data and substance for regulatory filings and responses related to impurity profiles and control strategies.

Basic Information

Product Name	n-Nitrosooxprenolol
CAS No.	96497-86-8
Molecular Formula	C15H22N2O4
Molecular Weight	294.35 g/mol
Synonyms	N-Nitrosooxprenolol; Oxprenolol Nitrosamine; 1-[(1-Methylethyl)amino]-3-[2-[(2-nitrosopropoxy)methyl]phenoxy]-2-propanol; 2-[2-Hydroxy-3-(isopropylamino)propoxy]benzyl Alcohol Nitrosopropanol Ether; N-Nitroso Oxprenolol; Oxprenolol N-Nitroso Derivative; Nitrosamine Derivative of Oxprenolol
EINECS	Contact for details

Quality Control

Every batch of n-Nitrosooxprenolol is manufactured and handled under strict quality management systems. The product undergoes rigorous analytical testing, including chromatographic purity assays and spectroscopic identification, to ensure it meets the high standards required for research and reference applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, purity, and related substances is provided with each shipment to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.