Description

Z-D-1-Nal-Oh is a protected amino acid derivative, specifically a Z-protected 1-naphthylalanine derivative, widely used as a key chiral building block in advanced organic synthesis. This high-purity intermediate is critical for ensuring the stereochemical integrity and yield of complex target molecules. It is essential for research and production in the pharmaceutical and biotechnology sectors, particularly in the development of peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel peptide drugs and bioactive compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the 1-naphthylalanine residue with orthogonal protection.
• Proteomics Research: Serves as a specialized building block for creating custom peptides and peptidomimetics in academic and industrial research.
• API Development: Employed in the research, development, and scale-up manufacturing of Active Pharmaceutical Ingredients (APIs) requiring non-natural amino acid motifs.
• Chemical Biology: Useful for synthesizing fluorescent or structurally modified peptide probes for studying protein interactions and functions.

Basic Information

Product Name	Z-D-1-Nal-Oh
CAS No.	96402-43-6
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-D-1-naphthylalanine; Z-D-1-Nal-OH; (R)-2-((((Benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic acid; N-Cbz-D-1-Naphthylalanine; Nα-Carbobenzoxy-D-1-naphthylalanine; D-Nα-Cbz-1-Nal; Z-D-Nal(1)-OH; Fmoc-D-1-Nal-OH precursor
EINECS	Contact for details

Quality Control

Our Z-D-1-Nal-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.