Description

Dehydro Felodipine-13C4 is a stable isotope-labeled analog of a key felodipine metabolite, where four carbon atoms are replaced with the carbon-13 isotope. This compound is essential as a high-purity internal standard for the accurate quantification of dehydro felodipine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioequivalence testing, and clinical research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for precise and accurate quantification of dehydro felodipine in plasma, serum, and other biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track and measure the primary active metabolite of felodipine in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Serves as a reference standard for developing robust, sensitive, and selective analytical methods.
• Clinical Research and Bioequivalence Testing: Ensures reliable data in human trials and generic drug development for cardiovascular medications.
• High-Purity Reference Material: Provides a certified standard for calibrating instruments and verifying analytical results in quality control laboratories.

Basic Information

Product Name	Dehydro Felodipine-13C4
CAS No.	96382-71-7
Molecular Formula	C18H15Cl2NO4 (with four 13C atoms)
Molecular Weight	~ 404.2 g/mol (exact mass varies with isotopic enrichment)
Synonyms	Felodipine Impurity C (13C4); 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester-13C4 (Dehydro); Dehydro Felodipine-13C4; [13C4]-Dehydro Felodipine; Felodipine Related Compound C (13C4); Isotopically Labeled Dehydro Felodipine; 1,4-Dihydro-2,6-dimethyl-4-(2,3-dichlorophenyl)-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester-13C4 (dehydro form)
EINECS	Contact for details

Quality Control

Our Dehydro Felodipine-13C4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive mass spectrometry applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % 13C), chemical purity (by HPLC), and identification (by NMR and MS). We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % 13C)	≥ 99% on the labeled positions
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.