Description

n-Acetyl-Eglin C is a chemically modified, potent protease inhibitor derived from the native Eglin C protein. This acetylation enhances its stability and specificity, making it a valuable tool for biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for studying inflammatory pathways, enzyme kinetics, and as a reference standard in quality control for related biopharmaceuticals.

Application

• Protease Inhibition Studies: Used as a specific inhibitor for chymotrypsin, cathepsin G, and subtilisin in enzymatic assays.
• Biopharmaceutical R&D: Serves as a reference compound and intermediate in the development of anti-inflammatory and anti-protease therapeutics.
• Biochemical Research: A key reagent for investigating protein-protein interactions, inflammatory cascades, and protease-related disease mechanisms.
• Quality Control Standard: Employed as an analytical standard in HPLC and other methods to ensure the purity and activity of related peptide-based products.
• Enzyme Characterization: Essential for determining kinetic parameters and inhibition constants (Ki) of serine proteases.

Basic Information

Product Name	n-Acetyl-Eglin C
CAS No.	96380-69-7
Molecular Formula	C254H403N71O78S2
Molecular Weight	~5810.5 g/mol
Synonyms	Acetylated Eglin C; N-Acetyleglin C; Eglin c, N-acetyl-; Eglin-C Acetate; Hirudinaria manillensis protease inhibitor derivative; Ac-Eglin C; Serine protease inhibitor (modified); LEKTI domain 6 inhibitor analog.
EINECS	Contact for details

Quality Control

Our n-Acetyl-Eglin C is produced and tested under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to relevant quality guidelines to support our global clientele in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Inhibition of chymotrypsin (IC50) conforms to reference

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.