Description

(2R,4R)-(+)-2,4-Bis(Diphenylphosphino)Pentane CAS NO 96183-46-9 is a high-value, chiral bidentate phosphine ligand essential for asymmetric catalysis. Its primary value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, a critical factor for producing optically pure intermediates in fine chemical and pharmaceutical synthesis. This ligand is particularly sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control for manufacturing advanced chiral molecules.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Employed in cross-coupling and allylic substitution reactions to construct chiral carbon frameworks with high optical purity.
• Catalyst Precursor Synthesis: Used to prepare well-defined chiral transition metal complexes (e.g., with Rh, Ru, Pd) for homogeneous catalysis.
• Pharmaceutical Intermediate Manufacturing: Facilitates the synthesis of chiral building blocks for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Applied in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A vital tool for methodological development in organic synthesis and process chemistry optimization.

Basic Information

Product Name	(2R,4R)-(+)-2,4-Bis(Diphenylphosphino)Pentane
CAS No.	96183-46-9
Molecular Formula	C29H30P2
Molecular Weight	440.50 g/mol
Synonyms	(R,R)-BDPP; (2R,4R)-(-)-2,4-Bis(diphenylphosphino)pentane; (R,R)-2,4-Bis(diphenylphosphino)pentane; (R,R)-(-)-2,4-Bis(diphenylphosphino)pentane; (2R,4R)-BDPP; SK-CC01-A; BDPP ligand; ChiraPhos
EINECS	Contact for details

Quality Control

Every batch of (2R,4R)-(+)-2,4-Bis(Diphenylphosphino)Pentane is manufactured and tested under strict quality management systems to ensure high chemical and optical purity, critical for reproducible catalytic performance. Our standard quality commitment includes comprehensive analysis via NMR, HPLC, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with full analytical data are provided for each lot, supporting compliance with cGMP and ISO 9001 standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening and stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.