Description

trans-4-Hydroxy-1-(4-Nitrobenzyloxycarbonyl)-L-Proline is a high-purity, protected amino acid derivative designed for advanced pharmaceutical synthesis and peptide research. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries developing novel therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected hydroxyproline derivative to introduce specific structural motifs.
• Bioconjugation & Linker Chemistry: The 4-nitrobenzyloxycarbonyl (PNZ) protecting group can be utilized in selective deprotection strategies or as a cleavable linker in prodrug design.
• Research & Development: Serves as a standard or reagent in academic and industrial R&D for studying peptide structure-activity relationships (SAR).
• Glycopeptide & Collagen Mimetic Synthesis: The trans-4-hydroxy-L-proline moiety is crucial for synthesizing collagen-like peptides and glycopeptides that mimic natural biological structures.
• Catalyst & Ligand Preparation: Can be used to create chiral catalysts or ligands for asymmetric synthesis, leveraging its rigid, functionalized pyrrolidine ring.

Basic Information

Product Name	trans-4-Hydroxy-1-(4-Nitrobenzyloxycarbonyl)-L-Proline
CAS No.	96034-57-0
Molecular Formula	C₁₃H₁₄N₂O₇
Molecular Weight	310.26 g/mol
Synonyms	1-[(4-Nitrophenyl)methoxycarbonyl]-4-hydroxy-L-proline; (2S,4R)-1-[(4-Nitrobenzyl)oxycarbonyl]-4-hydroxypyrrolidine-2-carboxylic Acid; L-Proline, 4-hydroxy-1-[(4-nitrophenyl)methoxy]carbonyl]-, trans-; PNZ-Hyp-OH; 4-Hydroxy-1-PNZ-L-proline; trans-4-Hydroxy-N-PNZ-L-proline; 1-PNZ-4-hydroxy-L-proline; trans-1-PNZ-4-Hyp-OH
EINECS	Contact for details

Quality Control

Our trans-4-Hydroxy-1-(4-Nitrobenzyloxycarbonyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (trans-4R isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.