Description

Eflornithine Hydrochloride Hydrate is a potent and selective inhibitor of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis. This mechanism of action makes it a critical active pharmaceutical ingredient (API) for targeted therapeutic applications. It is primarily utilized by pharmaceutical manufacturers and research institutions developing treatments for conditions involving uncontrolled cellular proliferation.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the systemic treatment of African trypanosomiasis (sleeping sickness).
• Topical Formulations: Key component in topical creams indicated for the reduction of unwanted facial hair in women (hirsutism).
• Oncology Research: Investigated in preclinical and clinical studies for its potential antiproliferative effects against certain cancers, including skin and colorectal cancers.
• Biochemical Research: Used as a specific tool compound in life science research to study polyamine metabolism and its role in cell growth, differentiation, and apoptosis.
• Dermatology R&D: Explored for applications in other dermatological conditions where regulation of hair follicle activity or rapid cell turnover is desired.

Basic Information

Product Name	Eflornithine Hydrochloride Hydrate
CAS No.	96020-91-6
Molecular Formula	C6H12F2N2O2 • HCl • xH2O
Molecular Weight	236.62 (anhydrous base)
Synonyms	DFMO Hydrochloride Hydrate; 2-(Difluoromethyl)ornithine Hydrochloride Hydrate; α-Difluoromethylornithine HCl Hydrate; (RS)-2-(Difluoromethyl)ornithine Monohydrochloride Hydrate; DL-α-Difluoromethylornithine Hydrochloride Hydrate; Eflornithine HCl Hydrate; Ornidyl (associated brand name)
EINECS	Contact for details

Quality Control

Our Eflornithine Hydrochloride Hydrate is manufactured under strict quality management systems. It is produced to meet exacting standards suitable for pharmaceutical applications, with comprehensive testing to ensure identity, purity, and potency. A Certificate of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and water content is provided with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	As per grade requirement
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.