Description

Fumagillin CAS NO 23110-15-8 is a potent antibiotic and antiprotozoal compound derived from the fungus *Aspergillus fumigatus*. It matters for its unique mechanism of action, specifically inhibiting angiogenesis and microsporidian proliferation, which makes it a critical tool in specific therapeutic and research contexts. This product is essential for pharmaceutical manufacturers, aquaculture operations, and life science researchers requiring a high-purity, reliable supply of this active pharmaceutical ingredient (API).

Application

• Pharmaceutical API: Primary use in the formulation of anti-microsporidiosis medications, particularly for treating intestinal infections like those caused by *Enterocytozoon bieneusi*.
• Aquaculture & Animal Health: Used to control and treat microsporidian parasites (e.g., *Nosema apis*) in honeybee colonies and in fish farming.
• Angiogenesis Research: Serves as a key biochemical tool in laboratory studies investigating endothelial cell proliferation and tumor growth inhibition due to its methionine aminopeptidase-2 (MetAP-2) inhibitory activity.
• Veterinary Medicine: Employed in treatments for parasitic infections in various animal species.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or pharmacopeial testing.

Basic Information

Product Name	Fumagillin
CAS No.	23110-15-8
Molecular Formula	C₂₆H₃₄O₇
Molecular Weight	458.55 g/mol
Synonyms	Fumagillin; Fumidil B; Amebacillin; Fugillin; NSC 9168; 5-[(1E,3E,5E,7E)-8-[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-8-oxoocta-1,3,5,7-tetraen-1-yl]-2-hydroxy-3-methoxybenzoic acid
EINECS	245-436-0

Quality Control

Our Fumagillin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and ensure long-term stability. The container should be kept in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.