Description

Pentamidine Isethionate is a synthetic antimicrobial diamidine compound primarily used as an antiprotozoal agent. It is a critical active pharmaceutical ingredient (API) essential for the formulation of injectable medications targeting serious opportunistic infections. This compound is vital for pharmaceutical manufacturers and research institutions developing treatments for conditions such as Pneumocystis pneumonia (PCP) and certain forms of leishmaniasis. Its reliable supply and consistent high purity are paramount for ensuring patient safety and therapeutic efficacy in clinical settings.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP).
• Antiprotozoal Drug: Used in the management of early-stage African trypanosomiasis (sleeping sickness) caused by *Trypanosoma brucei gambiense*.
• Leishmaniasis Treatment: Employed as a secondary therapeutic option for certain forms of visceral and cutaneous leishmaniasis.
• Research & Development: Serves as a key reference standard and biochemical tool in parasitology and antimicrobial research.
• Veterinary Medicine: Potential application in treating analogous protozoal infections in animals.
• Hospital Compounding: Used in specialized pharmacy compounding for patient-specific dosage forms where commercial preparations are unsuitable.

Basic Information

Item	Detail
Product Name	Pentamidine Isethionate
CAS No.	140-64-7
Molecular Formula	C23H36N4O10S2
Molecular Weight	592.70 g/mol
Synonyms	Pentamidine Diisethionate; 4,4'-[Pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide Di(2-hydroxyethanesulfonate); Lomidine (brand name); Pentacarinat (brand name); 1,5-Bis(4-amidinophenoxy)pentane Diisethionate; Pentamidine Dimesylate (common misnomer); Pentamidine Dimethanesulfonate (obsolete name)
EINECS	205-428-8

Quality Control

Our Pentamidine Isethionate is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs where applicable. Every batch undergoes comprehensive analytical testing for identity, potency, purity, and specific impurities to ensure it is suitable for pharmaceutical use. A comprehensive Certificate of Analysis (COA) documenting all test results against release specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be protected from humidity. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 5.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 2.0% Any individual impurity NMT 0.5%
Bacterial Endotoxins	< 0.5 EU/mg (for injectable grade)
Microbial Enumeration	Complies with USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.