Description

Propamidine Isetionate is a potent antimicrobial and antiseptic agent belonging to the aromatic diamidine class of compounds. Its primary value lies in its broad-spectrum activity against bacteria, fungi, and protozoa, making it a critical component in specialized pharmaceutical and ophthalmic formulations. This compound is essential for manufacturers in the pharmaceutical, veterinary medicine, and advanced wound care sectors requiring a reliable and effective preservative or active ingredient.

Application

• Ophthalmic Solutions: Used as a preservative and active ingredient in eye drops and contact lens solutions to prevent microbial contamination.
• Topical Antiseptics: Formulated into creams, ointments, and gels for the treatment of skin infections, burns, and minor wounds.
• Veterinary Pharmaceuticals: Incorporated into topical preparations for treating bacterial and fungal infections in animals.
• Preservative Systems: Serves as a stabilizing agent in multi-dose parenteral and non-sterile liquid formulations susceptible to microbial growth.
• Research & Development: Utilized as a reference standard and active compound in microbiological and pharmacological research studies.

Basic Information

Product Name	Propamidine Isetionate
CAS No.	140-63-6
Molecular Formula	C17H24N4O7S
Molecular Weight	428.46 g/mol
Synonyms	Propamidine Diisethionate; 4,4'-(Propane-1,3-diylbis(oxy))dibenzenecarboximidamide Diisethionate; Brolene (as active ingredient); Dibromopropamidine Isetionate (related compound); 1,3-Bis(4-amidinophenoxy)propane Diisethionate; Propamidine Di(2-hydroxyethanesulfonate); Propamidine Dimesylate (related salt); Amidines, aromatic (class)
EINECS	205-423-6

Quality Control

Our Propamidine Isetionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.