Description

Cortolone-3-Glucuronide is a significant conjugated metabolite of endogenous steroid hormones, specifically formed by the glucuronidation of cortolone. This compound is of critical importance in biochemical research and diagnostic applications, serving as a key reference standard and analytical marker. It is primarily utilized by research institutions, pharmaceutical developers, and clinical diagnostic laboratories for studies involving steroid metabolism, hormone profiling, and the development of sensitive detection assays.

Application

• Biochemical Research Standard: Serves as a high-purity reference compound for investigating steroid hormone metabolic pathways and conjugation mechanisms.
• Clinical Diagnostics: Used as a calibration standard in mass spectrometry (LC-MS/MS) and immunoassays for the quantitative analysis of steroid metabolites in biological samples (e.g., urine, serum).
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetic (DMPK) studies to understand the disposition and clearance of steroid-based therapeutics.
• Endocrinology Studies: A vital tool for profiling endogenous steroids, aiding in research related to adrenal function, reproductive endocrinology, and metabolic disorders.
• Quality Control: Acts as a system suitability standard in analytical method validation for laboratories performing steroid hormone testing.

Basic Information

Item	Details
Product Name	Cortolone-3-Glucuronide
CAS No.	95826-45-2
Molecular Formula	C27H40O9
Molecular Weight	508.60 g/mol
Synonyms	5β-Pregnane-3α,17α,20α,21-Tetrol-3-Glucuronide; 3α,17α,20α,21-Tetrahydroxy-5β-pregnan-3-yl-β-D-Glucopyranosiduronic Acid; β-Cortolone Glucuronide; Tetrahydrocortisone Glucuronide; Urocortisone Glucuronide; (3α,5β,17α,20α)-3,17,20,21-Tetrahydroxypregnan-3-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our Cortolone-3-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.