Description

1-n-Cbz-3-Hydroxy-Piperidine is a versatile and high-purity piperidine derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the protected amine (Cbz) and hydroxyl functionalities, which allow for selective and controlled chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various drug candidates, including central nervous system (CNS) agents, antiviral drugs, and enzyme inhibitors.
• Peptidomimetics & PROTACs: Used in constructing peptide backbones and linkers for Proteolysis Targeting Chimeras (PROTACs) due to its piperidine scaffold.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, and plant growth regulators.
• Asymmetric Catalysis: Employed as a ligand precursor or chiral auxiliary in stereoselective catalytic reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	1-n-Cbz-3-Hydroxy-Piperidine
CAS No.	95798-22-4
Molecular Formula	C13H17NO3
Molecular Weight	235.28 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-hydroxypiperidine; 3-Hydroxy-1-[(phenylmethoxy)carbonyl]piperidine; 1-Carbobenzoxy-3-hydroxypiperidine; 1-Cbz-3-piperidinol; 3-Hydroxy-N-Cbz-piperidine; 3-Hydroxy-1-(benzyloxycarbonyl)piperidine; 1-(Benzyloxycarbonyl)-3-piperidinol; Piperidine, 1-[(phenylmethoxy)carbonyl]-3-hydroxy-
EINECS	Contact for details

Quality Control

Every batch of 1-n-Cbz-3-Hydroxy-Piperidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.