Description

D 13223 (Flupirtine Metabolite) is a key organic intermediate and reference standard, specifically identified as a metabolite of the centrally acting analgesic flupirtine. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in bioanalytical method development, impurity profiling, and the production of high-purity drug substances.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of flupirtine and its metabolites in biological matrices.
• Metabolite Research: Critical for in-vitro and in-vivo studies to understand the metabolic pathways, bioavailability, and excretion profiles of flupirtine.
• Impurity Standard: Serves as a known impurity or degradation product standard for quality control and stability testing of flupirtine drug substance and finished dosage forms.
• Chemical Synthesis Intermediate: Employed as a building block in the research-scale synthesis of novel pharmaceutical compounds or labeled analogs for tracer studies.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or GC-MS methods in pharmacokinetic and toxicokinetic studies.

Basic Information

Product Name	D 13223 (Flupirtine Metabolite)
CAS No.	95777-69-8
Molecular Formula	C15H15FN4O2
Molecular Weight	302.31 g/mol
Synonyms	D-13223; Flupirtine Metabolite D13223; Ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}carbamate; Carbamic acid, N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-, ethyl ester; Ethyl [2-amino-6-[(4-fluorobenzyl)amino]-3-pyridinyl]carbamate; Flupirtine metabolite B; 2-Amino-6-[(4-fluorobenzyl)amino]-3-pyridinecarbamic acid ethyl ester
EINECS	Contact for details

Quality Control

Our D 13223 (Flupirtine Metabolite) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch undergoes rigorous analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.