Description

3-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Alanine is a specialized, high-value amino acid derivative featuring a photolabile diazirine group and a trifluoromethyl moiety. This compound is critical for advanced biochemical research, enabling precise, covalent cross-linking upon photoactivation for studying protein-protein interactions and biomolecular structures. It is primarily utilized by research scientists and process developers in pharmaceutical R&D, proteomics, and chemical biology for creating innovative photoaffinity probes and bioconjugation reagents.

Application

• Photoaffinity Labeling (PAL): A key building block for synthesizing probes to irreversibly tag and identify biological targets, such as enzymes and receptors, upon UV light exposure.
• Chemical Proteomics: Used in activity-based protein profiling (ABPP) to discover and validate drug targets and study protein function in complex biological systems.
• Bioconjugation & Linker Chemistry: Serves as a versatile linker for attaching fluorophores, affinity tags (e.g., biotin), or drugs to peptides, proteins, or other biomolecules.
• Structural Biology Studies: Facilitates the mapping of binding sites and interaction interfaces through covalent cross-linking, aiding in structure-based drug design.
• Precision Tool Development: Enables the creation of next-generation molecular tools for high-resolution imaging and diagnostic assay development.
• Material Science & Surface Functionalization: Applied in modifying surfaces with bioactive molecules for biosensor and microarray development.

Basic Information

Product Name	3-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Alanine
CAS No.	95758-95-5
Molecular Formula	C₁₂H₁₀F₃N₃O₂
Molecular Weight	285.22 g/mol
Synonyms	p-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-L-phenylalanine; 3-[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]-L-alanine; TFD-Phe; 3-(4-(3-(Trifluoromethyl)diazirin-3-yl)phenyl)alanine; Photoleucine analog; Diazirine-Phenylalanine; Photo-crosslinking amino acid; PAL Reagent
EINECS	Contact for details

Quality Control

Every batch of 3-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Alanine is manufactured and analyzed under strict quality management protocols. We guarantee high chemical purity and structural integrity, verified by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.