Description

2'-(O)-(n-(2-Aminoethyl)Carbamoylethyl)Phosphono-N(6)-(n-(2-Aminoethyl)Carbamoylethyl)Nad is a chemically modified derivative of nicotinamide adenine dinucleotide (NAD+), engineered with specific functional groups to enhance its utility in biochemical research and development. This compound is valued for its role as a specialized coenzyme analog, enabling advanced studies in enzymology, cellular metabolism, and signal transduction pathways. It is primarily sought by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, diagnostic assay development, and metabolic engineering.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate or inhibitor analog to investigate the catalytic mechanisms of NAD+-dependent enzymes like dehydrogenases, sirtuins, and PARPs.
• Biochemical Assay Development: Serves as a key component in developing high-throughput screening (HTS) assays for drug discovery targeting metabolic disorders and age-related diseases.
• Metabolic Pathway Research: Employed in cellular and mitochondrial studies to probe redox states, energy metabolism, and the function of specific NAD+-utilizing pathways.
• Protein Labeling & Conjugation: The reactive aminoethyl carbamoylethyl groups facilitate site-specific conjugation to proteins, antibodies, or solid supports for creating detection probes or affinity matrices.
• Diagnostic Reagent Formulation: Incorporated into diagnostic kits for the clinical measurement of specific enzyme activities or metabolites.
• Cofactor Engineering: Used in synthetic biology and biocatalysis to engineer novel enzymatic reactions or pathways that require customized NAD+ analogs.

Basic Information

Product Name	2'-(O)-(n-(2-Aminoethyl)Carbamoylethyl)Phosphono-N(6)-(n-(2-Aminoethyl)Carbamoylethyl)Nad
CAS No.	95754-68-0
Molecular Formula	C28H43N10O17P2
Molecular Weight	877.66 g/mol
Synonyms	NAD+ analog, aminoethylcarbamoylethyl-NAD; 2'-O-[2-[(2-Aminoethyl)amino]-2-oxoethyl]-N6-[2-[(2-aminoethyl)amino]-2-oxoethyl]-NAD; N6-[2-[(2-Aminoethyl)amino]-2-oxoethyl]-2'-O-[2-[(2-aminoethyl)amino]-2-oxoethyl]adenosine 5'-(trihydrogen diphosphate) P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium hydroxide, inner salt; Modified NAD derivative; Bifunctional NAD+ probe
EINECS	Contact for details

Quality Control

Our 2'-(O)-(n-(2-Aminoethyl)Carbamoylethyl)Phosphono-N(6)-(n-(2-Aminoethyl)Carbamoylethyl)Nad is produced under strict quality management protocols suitable for research and development. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and mass spectrometry data are provided and available upon request to support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.