Description

Acetamide, n-(3-Ethynylphenyl)-2,2,2-Trifluoro- is a specialized trifluoroacetamide derivative featuring a reactive ethynylphenyl group, making it a valuable building block in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a robust amide linkage with a terminal alkyne and a trifluoromethyl group, enabling precise chemical modifications. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients and functional materials. The CAS number for this compound is 95650-59-2.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and targeted therapy research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging the bioactivity of the trifluoromethyl group.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic frameworks (MOFs/COFs).
• Click Chemistry: The terminal alkyne group makes it an ideal substrate for Huisgen cycloaddition reactions, facilitating efficient bioconjugation and labeling.
• Ligand & Catalyst Development: Employed in the design of novel ligands for transition metal catalysis and organometallic complexes.
• Fluorine Chemistry Research: A valuable compound for studying the introduction and effects of fluorine atoms in organic molecules.

Basic Information

Item	Details
Product Name	Acetamide, n-(3-Ethynylphenyl)-2,2,2-Trifluoro-
CAS No.	95650-59-2
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	N-(3-Ethynylphenyl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-(3-ethynylphenyl)acetamide; 3-Ethynylphenyltrifluoroacetamide; 1-(3-Ethynylphenyl)-2,2,2-trifluoroethanone imide; TFAE; 95650-59-2; Acetamide, 2,2,2-trifluoro-N-(3-ethynylphenyl)-
EINECS	Contact for details

Quality Control

Our Acetamide, n-(3-Ethynylphenyl)-2,2,2-Trifluoro- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.