Description

Acetamide, n-(4-Ethynylphenyl)-2,2,2-Trifluoro- is a specialized trifluoroacetamide derivative featuring a terminal ethynylphenyl group, making it a valuable building block for advanced organic synthesis. This compound is engineered to serve as a key intermediate in the development of complex molecules, particularly in pharmaceutical and materials science research. It is essential for researchers and manufacturers in the fields of medicinal chemistry, agrochemicals, and functional polymer development who require high-purity, structurally precise intermediates.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and targeted therapy research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging its unique fluorinated structure for enhanced bioactivity and stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in click chemistry applications due to the reactive ethynyl group, enabling bioconjugation and labeling of biomolecules.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira coupling) to construct complex molecular architectures.

Basic Information

Product Name	Acetamide, n-(4-Ethynylphenyl)-2,2,2-Trifluoro-
CAS No.	95650-58-1
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	N-(4-Ethynylphenyl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-(4-ethynylphenyl)acetamide; 4-Ethynyltrifluoroacetanilide; 1-Ethynyl-4-(trifluoroacetamido)benzene; TFAA Ethynyl Aniline Derivative; (4-Ethynylphenyl)trifluoroacetamide; Acetamide, N-(4-ethynylphenyl)-2,2,2-trifluoro-; 95650-58-1
EINECS	Contact for details

Quality Control

Our Acetamide, n-(4-Ethynylphenyl)-2,2,2-Trifluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.