Description

Glycyl-Prolyl-Leucyl-2-Naphthylamide is a synthetic tripeptide derivative containing a 2-naphthylamide chromogenic group. This compound is primarily valued as a highly specific and sensitive chromogenic substrate for the detection and kinetic study of dipeptidyl peptidase IV (DPP-IV) enzyme activity. It is essential for researchers and manufacturers in the fields of biochemical research, pharmaceutical development, and diagnostic assay production. The product is supplied as a high-purity reagent to ensure reliable and reproducible results in enzymatic assays.

Application

• Enzymology Research: Primary substrate for the spectrophotometric or fluorometric assay of Dipeptidyl Peptidase IV (DPP-IV, CD26) activity.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential DPP-IV inhibitors for drug discovery, particularly for type 2 diabetes and immune-modulating therapies.
• Diagnostic Reagent Manufacturing: A key component in the formulation of clinical diagnostic kits for measuring DPP-IV levels in serum or plasma samples.
• Cell Biology & Immunology Studies: Employed to investigate the role of DPP-IV in T-cell activation, cancer biology, and other physiological processes.
• Biochemical Profiling: Used to study enzyme kinetics, specificity, and inhibition constants (Ki) for quality control in enzyme production.
• Academic & Industrial R&D: A critical tool for universities, contract research organizations (CROs), and biotech companies conducting proteolysis-related research.

Basic Information

Product Name	Glycyl-Prolyl-Leucyl-2-Naphthylamide
CAS No.	95574-38-2
Molecular Formula	C26H36N6O4
Molecular Weight	496.60 g/mol
Synonyms	Gly-Pro-Leu-2-Naphthylamide; GPL-2NA; H-Gly-Pro-Leu-2-Naphthylamide; DPP-IV Substrate; Dipeptidyl Peptidase IV Substrate; GPLeu2NA; 2-Naphthylamide-Gly-Pro-Leu; N-(2-Naphthyl)-Gly-Pro-Leu amide
EINECS	Contact for details

Quality Control

Every batch of Glycyl-Prolyl-Leucyl-2-Naphthylamide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance. Our quality system is designed to meet the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identification (IR), and other critical parameters is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Activity	Suitable for DPP-IV enzyme assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.