Description

7,8-Dihydroxy-N,n-Didesmethylchlorpromazine is a high-purity chemical intermediate and reference standard of significant interest in pharmaceutical research and development. This compound is a key metabolite and synthetic precursor in the study of phenothiazine-derived pharmaceuticals, offering critical insights into drug metabolism and activity. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in advanced neuropharmacology, metabolite identification, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis of chlorpromazine and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Serves as a critical metabolite in pharmacokinetic and pharmacodynamic studies to understand the biotransformation pathways of phenothiazine drugs.
• Chemical Synthesis Intermediate: Acts as a versatile building block for the synthesis of novel phenothiazine derivatives with potential therapeutic applications.
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS, and other chromatographic methods for impurity profiling and assay determination.
• Neuroscience Research: Utilized in *in vitro* and *ex vivo* studies to investigate the mechanisms of action and side-effect profiles of antipsychotic medications.
• Quality Control (QC) Testing: Essential for pharmaceutical QC laboratories to identify and quantify related substances in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	7,8-Dihydroxy-N,n-Didesmethylchlorpromazine
CAS No.	95574-30-4
Molecular Formula	C17H19ClN2O2S
Molecular Weight	362.86 g/mol
Synonyms	7,8-Dihydroxychlorpromazine; 2-Chloro-10-[3-(7,8-dihydroxy-10H-phenothiazin-10-yl)propyl]-10H-phenothiazine; 7,8-Dihydroxy-10-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-10H-phenothiazine; Chlorpromazine 7,8-dihydroxy metabolite; DDCPZ; N/A-Desmethylchlorpromazine Dihydroxy Derivative
EINECS	Contact for details

Quality Control

Our 7,8-Dihydroxy-N,n-Didesmethylchlorpromazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent oxidation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	Light yellow to tan powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.