Description

Alpha2-Macroglobulin is a high-purity plasma glycoprotein and a major broad-spectrum protease inhibitor. This product is essential for research and development in life sciences, providing a critical reagent for studying protease regulation, inflammatory pathways, and cellular signaling. It is primarily utilized by biotechnology firms, pharmaceutical R&D departments, and academic research institutions focused on immunology, biochemistry, and therapeutic discovery.

Application

• Biochemical Research: Used as a key reagent in enzymatic assays to study the inhibition kinetics of various proteases including serine, cysteine, metallo, and aspartic proteases.
• Diagnostic Development: Serves as a standard or component in the development of immunoassays and diagnostic kits for inflammatory and disease states.
• Cell Culture & Immunology: Employed in cell-based studies to modulate protease activity in media, investigating its role in inflammation, wound healing, and immune response.
• Pharmaceutical R&D: Acts as a tool compound for screening and validating novel therapeutic targets involved in protease-mediated diseases.
• Protein-Protein Interaction Studies: Utilized to investigate binding interactions with cytokines, growth factors, and other plasma proteins.

Basic Information

Product Name	Alpha2-Macroglobulin
CAS No.	95568-41-5
Molecular Formula	Contact for details
Molecular Weight	~720,000 Da (Tetramer)
Synonyms	α2-Macroglobulin; A2M; α-2-Macroglobulin; α-2-Macroglobulin; Human α-2-Macroglobulin; Plasma Protease Inhibitor; C3 and PZP-like α-2-Macroglobulin Domain-containing Protein 8; CPAMD8; Tetrameric Proteinase Inhibitor
EINECS	Contact for details

Quality Control

Our Alpha2-Macroglobulin is produced and tested under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological activity, meeting the exacting standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity (by SDS-PAGE and HPLC), functional activity, and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or desiccant where applicable.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Complies
Purity (SDS-PAGE, reduced)	> 90%
Assay (Functional Activity)	> 85% vs. reference standard
Endotoxin	< 1.0 EU/mg
Protein Content (Biuret)	Contact for details
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.