Description

Succinimidyl-4-(Bromoacetamido)Butanoate is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a sulfhydryl-reactive bromoacetamide group. This compound is essential for creating stable, covalent linkages between proteins, peptides, and other biomolecules, enabling advanced bioconjugation strategies. It is a critical tool for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and proteomics research, where precise and stable molecular conjugates are required.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Attaching fluorescent dyes, biotin, or other probes to cysteine residues for detection and analysis.
• Immobilization of Biomolecules: Covalent attachment of proteins or peptides to solid supports (e.g., beads, biosensor chips) via surface thiol groups.
• Crosslinking for Structural Studies: Investigating protein-protein interactions and complex structures in structural biology.
• Diagnostic Reagent Manufacturing: Creating stable enzyme-antibody conjugates used in ELISA and other immunoassays.
• Polymer Functionalization: Introducing reactive handles onto polymers or nanoparticles for subsequent bioconjugation.

Basic Information

Product Name	Succinimidyl-4-(Bromoacetamido)Butanoate
CAS No.	95413-05-1
Molecular Formula	C10H13BrN2O5
Molecular Weight	321.13 g/mol
Synonyms	NHS-Bromoacetamide; S-BAB; 4-((Bromoacetyl)amino)butanoic acid N-hydroxysuccinimide ester; N-Succinimidyl 4-(bromoacetamido)butanoate; Succinimidyl bromoacetamidobutyrate; Bromoacetamido butanoic acid NHS ester; SGBA; 4-(Bromoacetamido)butanoic Acid Succinimidyl Ester
EINECS	Contact for details

Quality Control

Our Succinimidyl-4-(Bromoacetamido)Butanoate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for research and in vitro diagnostic (IVD) use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.