Description

4-(Trifluoromethoxy) Benzeneacetic Acid Methyl Ester is a high-value fluorinated aromatic ester building block. This compound is critical for introducing the trifluoromethoxy (OCF₃) pharmacophore, a key structural motif known to enhance metabolic stability, lipophilicity, and bioavailability in active molecules. It is primarily sought by pharmaceutical R&D and agrochemical manufacturers for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group improves compound efficacy and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Intermediate in the synthesis of novel materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Advanced Material Research: Utilized in academic and industrial R&D for creating novel fluorinated polymers and specialty chemicals.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise fluorination.

Basic Information

Product Name	4-(Trifluoromethoxy) Benzeneacetic Acid Methyl Ester
CAS No.	95299-18-6
Molecular Formula	C₁₀H₉F₃O₃
Molecular Weight	234.17 g/mol
Synonyms	Methyl 2-[4-(Trifluoromethoxy)phenyl]acetate; Methyl (4-Trifluoromethoxyphenyl)acetate; 4-(Trifluoromethoxy)phenylacetic Acid Methyl Ester; p-(Trifluoromethoxy)phenylacetic Acid Methyl Ester; Methyl 4-(Trifluoromethoxy)benzeneacetate; 95299-18-6; Methyl 2-(4-(Trifluoromethoxy)phenyl)acetate
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethoxy) Benzeneacetic Acid Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and incompatible materials as indicated by its chemical properties. The container must be kept tightly closed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.