Description

Angiotensin I, Sar(1,7)-Val(5)- is a synthetic peptide analog of the endogenous hormone Angiotensin I, specifically modified with sarcosine (Sar) and valine (Val) substitutions. This engineered structure is critical for research into the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It serves as a valuable biochemical tool for pharmaceutical R&D, academic research, and diagnostic development, particularly in cardiovascular and renal disease studies.

Application

• Biochemical Research: Used as a reference standard and substrate in enzymatic studies of angiotensin-converting enzyme (ACE) and other proteases within the RAS pathway.
• Pharmaceutical Development: Acts as a key intermediate or analytical standard in the discovery and validation of novel antihypertensive drugs and cardiovascular therapeutics.
• Diagnostic Assays: Employed in the development and calibration of immunoassays (e.g., ELISA) and other in vitro diagnostic kits for measuring angiotensin-related peptides.
• Receptor Binding Studies: Utilized in competitive binding assays to study the affinity and specificity of angiotensin receptors (AT1, AT2).
• Metabolic Pathway Analysis: Aids in mapping the conversion cascade of angiotensin peptides to understand disease mechanisms.
• Quality Control: Serves as a high-purity standard for the quality assurance of related peptide APIs and finished pharmaceutical products.

Basic Information

Product Name	Angiotensin I, Sar(1,7)-Val(5)-
CAS No.	95262-83-2
Molecular Formula	C49H71N13O12
Molecular Weight	1010.2 g/mol
Synonyms	Sar(1,7)-Val(5)-Angiotensin I; [Sar1,Val5]Angiotensin I; [Sar1,Val5]-Ang I; Angiotensin I (1-10), [Sar1,Val5]-; Asp-Arg-Val-Tyr-Val-His-Pro-Phe; [Sar1,Val5]Ang-(1-10); Modified Angiotensin I; ACE Substrate Analog
EINECS	Contact for details

Quality Control

Our Angiotensin I, Sar(1,7)-Val(5)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and residual solvent levels are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.