Description

Atovaquone is a synthetic hydroxynaphthoquinone derivative, a high-purity active pharmaceutical ingredient (API) with significant therapeutic value. It is primarily valued for its potent antiprotozoal and antimalarial activity, targeting the mitochondrial electron transport chain of susceptible organisms. This compound is essential for pharmaceutical manufacturers developing treatments for opportunistic infections, particularly in immunocompromised patients, and for antimalarial formulations.

Application

• Antimalarial Drug Formulation: A key component in fixed-dose combination therapies, such as with proguanil, for the prophylaxis and treatment of Plasmodium falciparum malaria.
• Treatment of Opportunistic Infections: Used in the manufacture of medications for Pneumocystis jirovecii pneumonia (PCP), a serious infection common in HIV/AIDS patients.
• Veterinary Pharmaceutical Applications: Employed in developing antiprotozoal treatments for certain infections in animals.
• Pharmaceutical Research & Development: Serves as a reference standard and a critical intermediate in the synthesis and development of new therapeutic agents.
• Generic Drug Production: Supplied to manufacturers producing bioequivalent versions of branded atovaquone-containing medications.

Basic Information

Product Name	Atovaquone
CAS No.	95233-18-4
Molecular Formula	C22H19ClO3
Molecular Weight	366.84 g/mol
Synonyms	2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione; BW 566C80; 566C80; Mepron (Brand Name); Atovaquonum; Atovaquona; trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone
EINECS	Contact for details

Quality Control

Our Atovaquone is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling (related substances), and residual solvent analysis to ensure it meets stringent purity and safety criteria. A Certificate of Analysis (COA) documenting all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent any potential degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.