Description

Pro-Calcitonin Gene-Related Peptide (Pro-CGRP) is a significant neuropeptide precursor that plays a crucial role in vasodilation, neurotransmission, and inflammatory processes. Its primary commercial and research value lies in its direct relationship to the potent vasodilator Calcitonin Gene-Related Peptide (CGRP), making it a vital reference standard and intermediate in pharmaceutical development. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors, particularly those focused on cardiovascular, neurological, and migraine therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in the quality control and assay development of CGRP-targeting drugs.
• Biomedical Research: Critical for in vitro and in vivo studies investigating the biosynthesis, metabolism, and physiological role of CGRP.
• Diagnostic Kit Development: Serves as a key antigen or standard in the development of immunoassays (ELISA, RIA) for detecting CGRP or its precursors in clinical samples.
• Drug Discovery & Screening: Employed in high-throughput screening assays to identify and characterize novel compounds that modulate the CGRP pathway.
• Academic & Institutional Research: Supports fundamental neuroscience, cardiovascular, and pain research in university and government laboratories.
• Biologics Manufacturing: Acts as a process intermediate or a critical quality attribute marker during the production of peptide-based therapeutics.

Basic Information

Item	Detail
Product Name	Pro-Calcitonin Gene-Related Peptide
CAS No.	95077-07-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pro-CGRP; Calcitonin Gene-Related Peptide Precursor; CGRP-I (Precursor); Prepro-calcitonin gene-related peptide; CGRP Propeptide; CGRP(1-37) Precursor; α-CGRP Precursor
EINECS	Contact for details

Quality Control

Our Pro-Calcitonin Gene-Related Peptide is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, and other critical parameters are provided and available upon request to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.