Description

L-Mexiletine is the L-enantiomer of the Class IB antiarrhythmic agent Mexiletine. This specific stereoisomer is of significant interest in pharmaceutical research and development due to its distinct pharmacological profile and potential for targeted therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel cardiac medications and for studying stereoselective drug metabolism. The compound is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Pharmaceutical Reference Standard: Used as a certified standard in analytical laboratories for quality control and method development of Mexiletine-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of advanced pharmaceutical compounds targeting cardiac arrhythmias.
• Pharmacological Research: Employed in preclinical and clinical studies to investigate the stereospecific efficacy, pharmacokinetics, and safety profile of the L-enantiomer compared to the racemic mixture or the D-enantiomer.
• Metabolism and Toxicology Studies: Utilized in research to understand the enantioselective metabolism, distribution, and potential toxicological pathways of Mexiletine.
• Academic and Institutional Research: Applied in university and institutional labs for fundamental research in medicinal chemistry, cardiology, and chiral pharmacology.

Basic Information

Product Name	L-Mexiletine
CAS No.	94991-73-8
Molecular Formula	C11H17NO
Molecular Weight	179.26 g/mol
Synonyms	(2R)-1-(2,6-Dimethylphenoxy)-2-propanamine; (R)-Mexiletine; (-)-Mexiletine; L-(-)-Mexiletine; (R)-1-(2,6-Dimethylphenoxy)-2-propanamine; (R)-2-(2,6-Dimethylphenoxy)propylamine; Mexiletine L-isomer
EINECS	Contact for details

Quality Control

Our L-Mexiletine CAS NO 94991-73-8 is manufactured under strict quality control protocols to ensure high purity and consistency. Each batch is analyzed using advanced chromatographic and spectroscopic techniques to confirm identity, potency, and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for assay, enantiomeric excess, and related substances. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.