Description

S-(+)-Mexiletine is the pharmacologically active enantiomer of the class IB antiarrhythmic agent Mexiletine. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on precision medicine. The compound's specific stereochemistry is essential for ensuring targeted therapeutic efficacy and minimizing off-target effects in final drug formulations.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiopure (S)-Mexiletine hydrochloride API.
• Cardiovascular Drug Research: Used as a reference standard and starting material in R&D for novel sodium channel blockers and antiarrhythmic agents.
• Asymmetric Synthesis: Valuable chiral precursor for medicinal chemists exploring structure-activity relationships (SAR) in voltage-gated sodium channel modulators.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and chiral assay method development and validation.
• Preclinical & Clinical Development: Essential for formulating the active enantiomer in drug products during non-clinical and clinical trial stages.

Basic Information

Product Name	S-(+)-Mexiletine
CAS No.	94991-72-7
Molecular Formula	C11H17NO
Molecular Weight	179.26 g/mol
Synonyms	(S)-1-(2,6-Dimethylphenoxy)-2-propanamine; (S)-Mexiletine; (S)-1-Methyl-2-(2,6-xylyloxy)ethylamine; Dexmexiletine; (S)-(+)-Mexiletine; (S)-2-(2,6-Dimethylphenoxy)propylamine; (S)-2-Amino-1-(2,6-dimethylphenoxy)propane; KM-488
EINECS	Contact for details

Quality Control

Our S-(+)-Mexiletine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality assurance includes comprehensive testing for identity, purity, and chiral integrity, aligning with ICH guidelines for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each batch, documenting results for assay, enantiomeric excess (ee), and related substances by validated chiral HPLC methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (Chiral HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (ee)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.