Description

Boc-Ser(Tos)-Obzl CAS NO 94882-74-3 is a protected amino acid derivative, specifically a serine derivative with tert-butoxycarbonyl (Boc) and tosyl (Tos) protecting groups and a benzyl ester. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and reactivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of protected serine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methodologies for constructing peptide fragments and complex natural products.
• Pharmaceutical Research: Serves as a crucial starting material in the research and development of novel therapeutic peptides, hormones, and enzyme inhibitors.
• Process Chemistry & API Manufacturing: Employed in the scalable synthesis of peptide-based Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Development: Useful for creating modified peptides for biochemical assays, diagnostic probes, and targeted drug delivery systems.
• Academic & Institutional Research: A standard reagent in university and institutional labs for studying peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	Boc-Ser(Tos)-Obzl
CAS No.	94882-74-3
Molecular Formula	C22H27NO7S
Molecular Weight	449.52 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-(p-toluenesulfonyl)-L-serine benzyl ester; Boc-Ser(Tos)-OBzl; Boc-O-tosyl-L-serine benzyl ester; (2S)-3-[[(4-Methylphenyl)sulfonyl]oxy]-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid benzyl ester; Boc-L-Ser(Tos)-OBzl; Boc-Ser(Tos)-O-Bzl; tert-Butyloxycarbonyl-O-tosyl-L-serine benzyl ester; N-Boc-O-tosyl-L-serine benzyl ester
EINECS	Contact for details

Quality Control

Our Boc-Ser(Tos)-Obzl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure stereochemical integrity, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.